2 4-Difluorobenzoic acid (CAS# 1583-58-0)
Ngozi uye Kuchengeteka
| Hazard Symbols | Xi – Hasha |
| Risk Codes | 36/37/38 - Kushungurudza maziso, kufema system uye ganda. |
| Tsanangudzo Yekuchengetedza | S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa. S37/39 - Pfeka magirovhosi akakodzera uye dziviriro yeziso / kumeso |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Kirasi | IRRITANT |
Upstream Downstream Indasitiri
| Downstream Zvigadzirwa | 2,4-Difluorobenzotrifluoride 2,4-DIFLUORO-5-NITROBENZOIC ACID 3-bromo-2,6-difluorobenzoic acid 4-FLUORO-2-METHOXYBENZAMIDE METHYL 4-FLUORO-2-HYDROXYBENZOATE |
Nature
| kuchengetedza mamiriro | Yakavharwa pakaoma, Room Temperature |
| acidity coefficient (pKa) | 3.21±0.10(Zvakafanotaurwa) |
| kunyungudika kwemvura | SOLUBLE |
| BRN | 973355 |
| InChIKey | NJYBIFYEWYWYAN-UHFFFAOYSA-N |
| makemikari zvinhu | hupfu chena |
| use | mishonga uye liquid crystal intermediates. |
Chengetedzo ruzivo
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HazardClass | IRRITANT |
| tsika code | 29163990 |
Kushandisa uye synthesis nzira
Application
2, 4-difluorobenzoic asidhi yakakosha mushonga uye yepakati pesticide, senge 2, 4-difluorobenzoic asidhi inonyanya kushandiswa kugadzira antifungal zvinodhaka fluconazole, voriconazole uye mushonga wemishonga yepakati 4-fluorosalicylic acid, mushonga wepakati 3, 5-difluoro, nezvimwewo. 2, 4-difluorobenzoic acid inogona zvakare ishandiswe mumidziyo yekristaro yemvura, ine zvakanakira kukosha kwepamusoro uye tarisiro yakanaka yemusika.
Kugadzirira
Wedzera 2, 4-dinitrotoluene nemvura kumudziyo wekuita, gadzirisa pH kukosha ku7, simbisa uye kupisa kusvika 75 ° C. Potassium permanganate, magnesium sulfate uye phase transfer catalyst yakawedzerwa mumabhechi. Mushure mekuwedzera, ramba uchikurudzira uye uite pane imwe nguva tembiricha kwemaawa matatu. Sefa kuchipisa wogeza keke resefa nemvura inopisa. Batanidza iyo filtrate, acidify ne 35% hydrochloric acid kusvika pH 2-3, kune huwandu hukuru hwemvura yakachena mushure mekunge makristasi anyatso kunaya, kusefa, kugezwa, kudzokororwa, uye kuomeswa kuwana makristasi machena se2,4-dinitrobenzoic acid. . Chiyero che2, 4-dinitrotoluene kune potassium permanganate ndeye 2.4: 1. Chibereko chechibereko chedanho iri 90.7%.
wedzera N, N-dimethylmethylphthalamide mugaba rekuita, kupisa kusvika ku100 ~ 110 ℃, preheat ye 0.5 ~ 1h. Wedzera yakaomeswa anhydrous potassium fluoride pasi pekukurudzira uye chengetedza tembiricha preheated kwe0.5-1h. Mushure maizvozvi, 2, 4-dinitrobenzoic acid uye hexyltrimethylammonium bromide zvakakurumidza kuwedzerwa kumudziyo wekuita panguva imwe chete, uye kupisa kwakaramba kuchienderera mberi kusvika 120 ℃, kutonhora kwakachengetedzwa uye kugadzirisa kunokurudzira kwakaenderera mberi. Mushure me7h ye reflux reaction, iyo solvent inodzoserwa ne distillation, uye ipapo iyo inopindurwa mvura inonatswa nemhepo. Chikamu chakaunganidzwa chichena emulsion. Mushure mekumira kwenguva yakati rebei, chidimbu chakanangwa chemafuta chinonyura pasi, mvura yakachena yakachena pachikamu chepamusoro inodururwa, uye mafuta anotonhodzwa kuti awedzere makristasi machena kuti awane chigadzirwa chisina kuchena; iyo crude product inodzokororwa, Suction filtration, kuwacha, nekuomesa kuti uwane makristasi machena e2,4-difluorobenzoic acid. Chiyero chehuwandu hwe2, 4-dinitrobenzoic acid kusvika potassium fluoride ndeye 2.7: 1. Chibereko chechibereko chedanho iri 72.4%.
Nhanganyaya
2,4-Difluorobenzoic acid is an organic compound. Inotevera sumo yezvivakwa, kushandiswa, nzira dzekugadzirira uye ruzivo rwekuchengetedza ye2,4-difluorobenzoic acid:
Hunhu:
- Kuonekwa: 2,4-Difluorobenzoic acid ichena crystalline yakasimba.
- Solubility: Inonyungudika mune zvakajairika organic solvents senge ethanol, methanol uye methylene chloride.
Shandisa:
-Optical zvinhu: Inogona zvakare kushandiswa seimwe yezvakagadzirwa zvekugadzirwa kwezvinhu zvemaziso uye mafirimu optical.
- Maindasitiri ekushandisa: 2,4-difluorobenzoic acid inogona kushandiswa muindasitiri yemagetsi, machira uye mapurasitiki indasitiri ine anti-corrosion, anti-oxidation uye anti-ultraviolet mhedzisiro.
Nzira:
- 2,4-Difluorobenzoic acid inogona kuwanikwa ne fluorination ye hydrofluoric acid ine p-methylanisole.
Zvekuchengetedza
- Paunenge uchishanda, guruva rinofanira kudzivirirwa kudzivirira inhalation uye kuonana neziso. Panguva imwecheteyo, mamiriro akanaka ekufema anofanira kuchengetedzwa.
-Dzivisa kusangana neakasimba oxidizing agents kana maasidhi akasimba kudzivirira kuita zvine njodzi
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