2-Chloro-3-fluoro-6-picoline (CAS# 374633-32-6)

Nhanganyaya

Chitarisiko: Kazhinji isina ruvara kune yakavheneka yero mvura, chimiro chechimiro ichi chinoreva kuti chinogona kunzwira chiedza uye kupisa, uye zvinodikanwa kutora matanho ekudzivirira mwenje uye tembiricha kutonga panguva yekuchengeta uye yekufambisa, sekushandisa mabhodhoro egirazi ebrown nekuachengeta. muimba yekuchengetera inotonhorera kudzivirira kuwedzera kwemavara uye kuderera.

Solubility: Mushonga une kunyungudika kwakanaka mune zvakajairika organic solvents, senge toluene uye dichloromethane, inotevera musimboti wekunyungudika kwakafanana, uye ine hukama neorganic solvents kuburikidza nechikamu chehydrophobic chemorekuru; Zvisinei, kunyungudika mumvura kwakaderera, uye kusungirirwa kwakasimba kwehydrogen pakati pemamorekuru emvura kwakaoma kunyatsoputswa nemorekuru, zvichiita kuti zviome kuiparadzira.
Boiling point uye density: Data yepoindi yekubikira ine hukama zvakanyanya nekusagadzikana kwayo uye inogona kupa zvakakosha maparamita ekuita senge distillation uye kucheneswa, asi zvinosuwisa kuti kukosha kwekubikira kwacho hakuna kuburitswa pachena. Huremu hwayo hwakakwira zvishoma pane iyo yemvura, uye kunzwisisa density inogona kubatsira kunyatso fungira hukama-huwandu hwekushandurwa kwehukama mukuedza mashandiro kana maindasitiri maitirwo ekufambisa kwemvura uye nemamita chaiwo.
Chemical properties
Substitution reaction: Iyo chlorine atomu uye fluorine atomu mumorekuru ndiyo inogona kuita nzvimbo dzekuita. Mune nucleophilic substitution reaction, nucleophiles yakasimba inogona kurwisa nzvimbo iyo chlorine uye maatomu efluorine aripo, kutsiva maatomu anoenderana, uye kugadzira zvitsva zvepyridine. Semuenzaniso, yakave yakabatanidzwa nemamwe nucleophiles ane nitrogen uye sarufa kuti agadzire mutsara wenitrogen-containing heterocyclic compounds ane mamwe maitiro akaoma ekutsvaga zvinodhaka kana kugadzirwa kwezvinhu.
Redox reaction: iyo pyridine ring pachayo inenge yakagadzikana, asi kana maoxidants akasimba, akadai se potassium permanganate uye hydrogen peroxide akabatanidzwa nemamiriro ezvinhu ane acidic, oxidation inogona kuitika, zvichiita kuti kuparadzwa kana kuchinjwa kweiyo pyridine ring ring; Sezvineiwo, neakakodzera kudzikisa agent, senge simbi hydrides, zvinotemerwa zvinogoneka kune hydrogenation ye intramolecular unsaturated bonds.
Chechina, nzira yekubatanidza
Iyo yakajairika synthesis nzira ndeyekutanga kubva nyore pyridine derivatives uye zvishoma nezvishoma kuvaka iyo inotarirwa chimiro kuburikidza nehalogenation uye fluorination maitiro. Zvinyorwa zvekutanga zvepyridine zvinotanga zvakasarudzwa methylated uye mapoka emamethyl anounzwa panguva imwe chete; Wobva washandisa halogenation reagents, senge chlorine uye liquid chlorine, ine akakodzera catalysts uye maitiro ezvinhu, kuti vabudirire kuunzwa maatomu eklorini; Pakupedzisira, fluorinated reagents, akadai Selectfluor, akashandiswa zvakarurama fluorinate nzvimbo yaitarisirwa kuwana 2-chloro-3-fluoro-6-methylpyridine.
Uses
Drug synthesis intermediates: chimiro chayo chakasiyana chinodiwa nevemishonga yemishonga, uye ndeyepamusoro-soro yepakati yekugadzirwa kwemishonga mitsva yeantibacterial, antiviral, uye antitumor. Zvinhu zvemagetsi uye chimiro chepakati chepyridine zvindori uye zvinotsigira zvinogona kunyatsosunga kune chinangwa cheprotein mu vivo, uye zvinotarisirwa kuchinjwa kuva zvinhu zvinoshanda nekubudirira kwakanakisisa mushure mekutevera kuchinjwa kwematanho akawanda.
Materials science: Mumunda we organic material synthesis, inogona kushandiswa kugadzira inoshanda polymer zvinhu, fluorescent zvinhu, nezvimwewo, nekuda kwekugona kwayo kusuma nemazvo chlorine, fluorine maatomu uye pyridine zvimiro, endow zvinhu zvine akakosha magetsi uye anopenya. zvivakwa, uye kusimudzira kuvandudzwa kwetekinoroji yekucheka-kumucheto senge zvinhu zvakangwara uye zvekuratidzira zvinhu.