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5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7) Mufananidzo
  • 5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7) 1

5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)

Chemical Property:

Molecular Formula C5H3BrN2O3
Molar Misa 218.99
Density 1.98±0.1 g/cm3(Zvakafanotaurwa)
Melting Point 246-250 °C
Boling Point 296.7±40.0 °C(Zvakafanotaurwa)
Flash Point 133.2°C
Solubility DMSO, Methanol
Vapor Presure 0.00141mmHg pa25°C
Chitarisiko Solid
Color Yero
BRN 383853
pKa 6.31±0.10(Zvakafanotaurwa)
Storage Condition Inert mamiriro, Room Temperature
Refractive Index 1.647
MDL MFCD00023473

Product Detail

Product Tags

Ngozi uye Kuchengeteka

Risk Codes R22 – Zvinokuvadza kana ikamedzwa
R37/38 - Inogumbura kune yekufema system uye ganda.
R41 - Njodzi yekukuvara kwakakomba kwemaziso
R36/37/38 - Kushungurudza maziso, kufema system uye ganda.
R20 – Zvinokuvadza nekufema
Tsanangudzo Yekuchengetedza S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa.
S36/37/39 - Pfeka zvipfeko zvekudzivirira zvakakodzera, magurovhosi uye kudzivirira kweziso/chiso.
S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
UN IDs 2811
WGK Germany 3
HS Code 29337900
Hazard Note Zvinokuvadza
Hazard Kirasi IRRITANT

Reference Information

Shandisa 5-bromo-2-hydroxy-3-nitropyridine is organic intermediate inogona kushandiswa kugadzira makomisheni 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)-[1,1'-biphenyl. ]-4-yl) ethyl) -5-(pyrrole
alkyl-1-yl-sulfonyl) pyridin-2 (1H) -imwe, musanganiswa uyu iDOCK1 inhibitory compound.
synthesis nzira nitric acid (60-61%,3.5mL) yakawedzerwa kune mhinduro (10mL) ye5-bromopyridine -2 (1H) -imwe (1.75g,10.1mmol) mu sulfuric acid pa 0 ℃. Iko kusanganiswa kunobvumirwa kupisa kusvika kumhepo yekupisa uye kukurudzirwa kwemaawa matatu. Iyo reaction musanganiswa inodururwa mumvura yechando uye inokonzeresa precipitate inounganidzwa nekusefa. Chigadzirwa chinoguma chakashambidzwa nemvura uye chakaomeswa muvacuum, ichipa 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% goho) sechichena chakasimba. 1H
NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H).
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