5-Fluorocytosine (CAS# 2022-85-7)
Ngozi uye Kuchengeteka
| Risk Codes | R40 - Humbowo hushoma hwekuita carcinogenic R36/37/38 - Kushungurudza maziso, kufema system uye ganda. R63 - Ngozi inogoneka yekukuvadza kumwana asati azvarwa |
| Tsanangudzo Yekuchengetedza | S22 - Usafeme guruva. S24/25 - Dzivisa kusangana neganda nemeso. S45 - Kana waita tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga rubatsiro rwekuchipatara nekukasika (ratidza chinyorwa pese pazvinogoneka.) S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi. S36/37/39 - Pfeka zvipfeko zvekudzivirira zvakakodzera, magurovhosi uye kudzivirira kweziso/chiso. S27 - Bvisa pakarepo zvipfeko zvese zvakasvibiswa. S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa. |
| WGK Germany | 2 |
| RTECS | HA6040000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29335990 |
| Hazard Note | Chepfu/Chiedza Chinonzwa |
| Hazard Kirasi | IRRITANT, CHIEDZA CHINONZWA |
| Muchetura | LD50 mumakonzo (mg/kg):> 2000 nemuromo uye sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Nhanganyaya
quality
Ichi chigadzirwa chichena kana chisina-white crystalline powder, chisina kunhuwa kana kuti chinonhuwa zvishoma. Kunyungudika zvishoma mumvura, kunyungudika kwe1.2% pa20 °C mumvura, kunyungudika zvishoma mu ethanol; Inenge isingasviki mu chloroform uye ether; Soluble in dilute hydrochloric acid kana dilute sodium hydroxide solution. Iyo yakagadzikana pakupisa kwekamuri, inonaya makristasi kana ichitonhora, uye chikamu chidiki chinoshandurwa kuita 5-fluorouracil kana ichipisa.
Ichi chigadzirwa iantifungal drug synthesized muna 1957 uye yakashandiswa mukiriniki yekudzidzira muna 1969, ine pachena antibacterial mhedzisiro paCandida, cryptococcus, coloring fungi uye Aspergillus, uye hapana inhibitory maitiro pane mamwe fungi.
Iyo inhibitory effect pane fungi inokonzerwa nekupinda kwayo mumasero ehutachiwana hwefungi, apo pasi pekuita kwe nucleopyine deaminase, inobvisa mapoka emamino kuti aumbe antimetabolite-5-fluorouracil. Iyo yekupedzisira inoshandurwa kuita 5-fluorouracil deoxynucleoside uye inhibits thymine nucleoside synthetase, inovhara kutendeuka kweuracil deoxynucleoside kuita thymine nucleoside, uye inokanganisa DNA synthesis.
use
Antifungals. Inonyanya kushandiswa mucocutaneous candidiasis, candidal endocarditis, candidal arthritis, cryptococcal meningitis uye chromomycosis.
Kushandiswa uye chipimo cheOral, 4 ~ 6g pazuva, yakakamurwa kuita 4 nguva.
kuchengeteka
Kuverengwa kweropa kunofanira kuongororwa nguva dzose panguva yehutungamiri. Varwere vane chiropa uye itsvo kusakwana uye zvirwere zveropa uye vakadzi vane pamuviri vanofanira kushandisa nekuchenjerera; Contraindicated kune varwere vane yakanyanya renal insufficiency.
Shading, kuchengetedzwa kwemhepo.
