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5-Fluorouracil (CAS# 51-21-8) Mufananidzo
  • 5-Fluorouracil (CAS# 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Chemical Property:

Molecular Formula C4H3FN2O2
Molar Misa 130.08
Density 1.4593 (kufungidzira)
Melting Point 282-286 °C (Dec.) (lit.)
Boling Point 190-200°C/0.1mmHg
Mvura Solubility 12.2 g/L 20 ºC
Solubility Zvishoma soluble mu ethanol. Iyo inenge isinganyungudika mu chloroform uye yakanyungudutswa mu sodium hydroxide solution.
Chitarisiko Muchena kana chena-kunge crystalline poda
Color chena
Merck 14,4181
BRN 127172
pKa pKa 8.0±0.1 (H2O) (Hazvina chokwadi);3.0±0.1(H2O) (Hazvina chokwadi)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Storage Condition 2-8°C
Kugadzikana Yakagadzikana. Chiedza chinonzwa. Inopisa. Hazvienderani neakasimba oxidizing agents, mabhesi akasimba.
Sensitive Air Sensitive
Refractive Index 1.542
MDL MFCD00006018
Zvenyama uye Chemical Properties nzvimbo yekunyunguduka
solubility H2O: 10 mg/mL, yakajeka

fomu hupfu

ruvara ruchena

kunyungudika kwemvura 12.2g/L 20 oC
Sensitive Air
merck 14,4181
BRN 127172
Shandisa Kune digestive system cancer, gomarara remusoro nemutsipa, gomarara revakadzi, kenza yemapapu, kenza yechiropa, dundira uye kurapwa gomarara reganda.

Product Detail

Product Tags

Risk Codes R22 – Zvinokuvadza kana ikamedzwa
R20/21/22 – Zvinokuvadza nekufema, kubata ganda uye kana ikamedzwa.
R52 – Zvinokuvadza kune zvipenyu zvemumvura
R25 – Muchetura kana ukamedzwa
Tsanangudzo Yekuchengetedza S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
S36/37/39 - Pfeka zvipfeko zvekudzivirira zvakakodzera, magurovhosi uye kudzivirira kweziso/chiso.
S22 - Usafeme guruva.
S45 - Kana waita tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga rubatsiro rwekuchipatara nekukasika (ratidza chinyorwa pese pazvinogoneka.)
S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
RTECS YR0350000
FLUKA BRAND F CODES 10-23
TSCA T
HS Code 29335995
Hazard Note Irritant / Highly Toxic
Hazard Kirasi 6.1
Packing Group III
Muchetura LD50 nemuromo muTsuro: 230 mg/kg

 

Nhanganyaya

Ichi chigadzirwa chinotanga kushandurwa kuita 5-fluoro-2-deoxyuracil nucleotides mumuviri, iyo inhibisa thymine nucleotide synthase uye inovhara kutendeuka kwe deoxyuracil nucleotides kuita deoxythymine nucleotides, nokudaro inhibiting DNA biosynthesis. Mukuwedzera, nekudzivirira kubatanidzwa kweuracil uye rotic acid muRNA, mhedzisiro yekudzivisa RNA synthesis inowanikwa. Ichi chigadzirwa chesero cycle cycle chaiyo mushonga, kunyanya inhibiting S phase cells.

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