Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8)
Nhanganyaya
Z-Glu-OBzl(Z-Glu-OBzl) musanganiswa weorganic unowanzo shandiswa seboka rekuchengetedza amino acids. Iyi inotevera tsananguro yezvivakwa, mashandisiro, kugadzirira uye kuchengetedza ruzivo rwekomboni:
Zvakasikwa:
-Molecular formula: C17H17NO4
-Molecular uremu: 303.32g / mol
-Kuonekwa: White crystalline powder
-Kunyungudika: 84-85°C
-Solubility: Soluble mu organic solvents akadai dimethyl sulfoxide uye dimethylformamide
- Cbz inodzivirira boka inogona kubviswa ne palladium hydride catalyst pasi pe acidic mamiriro
Shandisa:
- Z-Glu-OBzl iboka rinodzivirira re glutamic acid (Glu), iyo inogona kushandiswa mukugadzirwa kweamino acid derivatives, polypeptides uye mapuroteni.
-Seboka rinodzivirira reamino acids mukugadzirwa kwezvinhu zvakasanganiswa, rinogona kudzivirira boka reamine re glutamic acid, kudzivirira kuti rirege kukanganiswa nemaitiro asina kujeka, uye kufambisa kubviswa pazvinenge zvichidiwa.
Kugadzirira nzira:
-Kugadzirira kweZ-Glu-OBzl kunowanzobatanidza maitiro akawanda-nhanho uye kunosanganisira mutsara wemakemikari maitiro. Imwe yenzira dzakajairika ndeyekutanga kuchengetedza boka recarboxyl re glutamic acid se t-butoxycarbonyl ester (Boc) uyezve kudzivirira boka reamino seCbz. Pakupedzisira, chigadzirwa chinodiwa Z-Glu-OBzl chinoumbwa nekuita ne benzyl chloroformate.
Zvekuchengetedza
- Z-Glu-OBzl inofanira kubatwa semishonga inogumbura uye kudzivisa kusangana kwakananga neganda nemaziso.
-Kana yakashandiswa murabhoritari, nzira dzekuchengetedza dzakafanira dzinofanirwa kuteverwa, kusanganisira kupfeka magirazi ekudzivirira, magirovhosi uye majasi emurabhoritari.
-Inhalation kana kupinza kwekomboni kunofanira kudziviswa uye moto uye kuputika matanho ekudzivirira anofanira kutorwa panguva yekuchengetedza.
-Mushonga unofanirwa kuiswa munzvimbo ine mhepo yakanaka panguva yekugadzirisa, uye tsvina inofanira kuraswa zvakakodzera maererano nemitemo yemunharaunda.
