dabigatran etexilate (CAS# 211915-06-9)

Chemical Property:

Molecular Formula	C34H41N7O5
Molar Misa	627.73
Density	1.24±0.1 g/cm3(Zvakafanotaurwa)
Melting Point	128-129°
Boling Point	827.9°C pa760 mmHg
Flash Point	454.5°C
Solubility	DMSO (Zvishoma), Methanol (Zvishoma)
Vapor Presure	1.49E-27mmHg pa25°C
Chitarisiko	Solid
Color	Muchena kusvika Payero Yero
pKa	9.88±0.46(Zvakafanotaurwa)
Storage Condition	Yakavharwa pakaoma,Chengeta mufiriji, pasi pe -20°C
Kugadzikana	Hygroscopic
Refractive Index	1.614
In vitro kudzidza	Dabigatran inosarudza uye inodzokera shure inhibits thrombin yevanhu (Ki: 4.5 nM) uye thrombin-induced platelet aggregation (IC50: 10 nM) uye haina inhibitory effect pane mamwe maplatelet stimulating agents. Dabigatran inhibisa chizvarwa che (PPP) thrombin mu plasma yeplatelet yakapera ine IC50 ye 0.56 μm sezvinoyerwa ne endogenous thrombin Index (ETP). In in vitro kuyedza, Dabigatran ine concentration-inotsamira anticoagulant mhedzisiro pamhando dzakasiyana siyana. MuPPP yevanhu, iyo activated partial thromboplastin time (aPTT), prothrombin time (PT) yakapetwa kaviri pazvikamu zve 0.23,0.83 uye 0.18 μm, zvichiteerana. Uye Ecarin clotting nguva (ECT)..
In vivo kudzidza	Dabigatran dose-inotsamira kwenguva yakareba APPT mushure mekutonga kwemutsinga mumakonzo (0.3,1 uye 3 mg/kg) uye rhesus tsoko (0.15,0.3 uye 0.6 mg/kg). Dabigatran etexilate (20 mg / kg, PO) yakabudisa zvishoma kuwedzera kwek kukosha uye kuderera kwekuwedzera kwekuwedzera kwenguruve kupfuura enoxaparin. Dabigatran (0.01-0.1 mg/kg) dose-inotsamira yakaderedzwa thrombosis, ine ED50 (50% inoshanda dose) iri 0.033 mg/kg uye inhibition yakakwana pa 0.1 mg/kg. Dabigatran etexilate (5-30 mg / kg) inhibited thrombus kuumbwa mune imwe nguva-uye-inotsamira nzira, ine yakanyanya inhibition inoitika mushure memaminitsi makumi matatu ekutanga, zvichiratidza kukurumidza kuita chiito.

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Nhanganyaya

Dibutyl phthalate ndeye organic compound. Imvura isina ruvara kusvika kuchiedza yero ine kunhuwirira kwakakosha.

Dabigatran etexilate inonyanya kushandiswa seplasticizer. Inogona kuwedzera kupfava uye ductility yemapurasitiki, saka inoshandiswa zvakanyanya mukugadzira zvigadzirwa zvepurasitiki, senge mafirimu epurasitiki, mapaipi epurasitiki, epurasitiki pasi uye shangu dzepurasitiki. Inogonawo kushandiswa sechinhu chinowedzera kune zvinonyungudutsa, mafuta uye zvinonhuhwirira.

Dabigatran etexilate inowanzogadzirirwa ne esterification ye phthalic anhydride ine n-butanol kana isobutanol. Kuita kunowanzoitwa pamberi peiyo acid catalyst pane yakakodzera tembiricha uye kumanikidza.

Inogona kutsamwisa ganda uye maziso uye inofanira kushambidzwa nemvura yakawanda pakarepo mushure mekubatana. Dzivisa kuita nemaoxidants, kudzivirira zvitubu zvekubatidza uye kure nekupisa kwakanyanya uye nemirazvo yakavhurika panguva yekushanda nekuchengetedza. Inofanirwa kunge ichifefeterwa zvakanaka panguva yekushandiswa kudzivirira kuunganidzwa kwemhute.

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