FMOC-Arg(Pbf)-OH (CAS# 154445-77-9)
Ngozi uye Kuchengeteka
| Hazard Symbols | Xi – Hasha |
| Risk Codes | 36/37/38 - Kushungurudza maziso, kufema system uye ganda. |
| Tsanangudzo Yekuchengetedza | S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa. S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera. |
| WGK Germany | 1 |
| HS Code | 2935 90 90 |
| Hazard Kirasi | IRRITANT |
Nhanganyaya
The FMOC-protecting group inowanzoshandiswa amino acid kuchengetedza boka rinochengetedza amino functional group rearginine. Iyi inotevera sumo kune zvimwe zvezvivakwa, kushandiswa, nzira dzekugadzirira, uye ruzivo rwekuchengetedza yeFmoc-Protective Radical:
Hunhu:
Iyo FMOC-inodzivirira boka iboka rinobvisika rinodzivirira rinodzivirira amino amino mapoka. Inogona kuita neboka reamino mu arginine kuburikidza ne esterification reaction kuti iite Fmoc-arginine ester, kuitira kuti uwane chinangwa chekudzivirira boka reamino. Kune mapoka anonhuhwirira ari paFmoc-protecting group molecule inobata zvakasimba UV mwenje, inobvumira kubviswa kweboka reFmoc-inodzivirira kuti riitwe ne UV irradiation kana makemikari nzira.
Shandisa:
Mapoka ekudzivirira eFOC anoshandiswa zvakanyanya mu peptide synthesis uye solid-phase synthesis. Inogona kudzivirira zvinobudirira iyo arginine amino boka kudzivirira maitiro ayo eparutivi panguva yekubatanidza. Mune peptide synthesis, boka rekudzivirira Fmoc rinogona kubviswa nemamiriro ealkaline, zvichibvumira kuumbwa kwepolypeptides kuenderera.
Nzira:
Iyo Fmoc-inodzivirira boka inogona kugadzirirwa nekuita kweFmoc-Cl uye arginine. Fmoc-Cl iine acidic reagent yakasimba iyo inopindirana neboka reamino muarginine kuumba Fmoc-arginine ester. Mhedzisiro yacho inowanzoitwa mu ethanol pane tembiricha yekamuri kusvika kune tembiricha yekugezera echando.
Zvekuchengetedza
FMOC-Protective Radicals yakachengeteka kushandiswa pasi pezvakajairwa marabhoritari mamiriro, asi zvinotevera zvinofanirwa kucherechedzwa:
- FMOC-CL inogumbura uye ine muchetura mumiriri, kutarisirwa kunofanirwa kutorwa kuti usasangana neganda, inhalation kana kupinza. Shanda munzvimbo inofefeterwa nemhepo uye pfeka midziyo yekuzvidzivirira nayo yakakodzera.
- FMOC-Protective Base ine pfuma yekunyura kwakasimba kwemirairo ye ultraviolet, saka kutarisirwa kunofanira kutorwa kudzivirira kusangana kwakananga neganda nemaziso panguva yekushandiswa, uye kuchengetedza kure nemagetsi akasimba.
- Yakasimba acid hydrolysis kudzivirira yakadai se pentafluorophenylcarboxylic acid (TFA) inowanzoshandiswa panguva yekubviswa kwemapoka ekudzivirira Fmoc, uye zvakakosha kuziva kuti mhute yeTFA inogona kukonzera kukanganisa, saka zvakakosha kushanda mune zvakanaka- nzvimbo ine mhepo.
