FMOC-D-NVA-OH (CAS# 144701-24-6)

FMOC-D-NVA-OH (CAS# 144701-24-6) iboka rinodzivirira amino acid rinowanzoshandiswa mukugadzira peptides nemapuroteni. Iyi inotevera tsananguro yechimiro, kushandiswa, kugadzira uye kuchengetedza ruzivo rwefmoc-D-norvaline:

Zvakasikwa:
fmoc-D-norvaline ichena yakasimba, kazhinji iri muchimiro chehupfu. Iyo inonyungudika zvakanaka mukunyungudutsa midziyo yakadai seN, N-dimethylformamide (DMF) kana dichloromethane (DCM). Mushonga wacho une high thermal stability uye unogona kugadzikana mune zvakajairika organic solvents.

Shandisa:
fmoc-D-norvaline inonyanya kushandiswa seboka rinodzivirira amino acid mukugadzirwa kwepeptides nemapuroteni. Inogona kubatanidzwa kune mamwe amino acids ne-soli-phase synthesis, iyo inogona kuchengetedza kwenguva pfupi mamwe amino acid panguva yekubatanidza. Kana peptide chain synthesis yapera, boka rekudzivirira reFmoc rinogona kubviswa nekurapa kwekutanga.

Nzira:
fmoc-D-norvaline inowanzogadzirirwa nemakemikari synthesis, ine D-norvaline sechinhu chekutanga. Iyo synthesis inosanganisira reacting norvaline neFmoc kudzivirira boka kusuma boka reFmoc nekutsiva maitiro. Pakupedzisira tora fmoc-D-norvaline.

Zvekuchengetedza
fmoc-D-norvaline yakachengeteka pasi pezvakajairwa murabhoritari mamiriro ekushanda, mamwe maitiro ekutanga ekushandisa achiri kuda kuteverwa. Dzivisa kusangana neganda nemaziso panguva yekushandiswa, uye iva nechokwadi chekuti unoshanda munzvimbo ine mhepo yakanaka. Midziyo yekuzvidzivirira yakafanira, senge magirovhosi emurabhoritari uye magirazi ekuchengetedza, zvinofanirwa kupfekwa pakubata mukomboni. Mukuwedzera, tsvina inofanira kuraswa zvakanaka uye kuraswa maererano nemitemo yakakodzera. Kana imwe tsaona yetsaona ikaitika, matanho erubatsiro ekutanga anoenderana anofanirwa kutorwa nekukurumidza. Mukushandiswa uye kuchengetedza fmoc-D-norvaline, iyo yakakodzera makemikari ekuchengetedza mitemo inofanirwa kucherechedzwa.