fmoc-O-tert-butyl-D-tyrosine (CAS# 118488-18-9)

Fmoc-O-tert-butyl-D-tyrosine inowanzoshandiswa yakachengetedzwa amino acid. Inotevera rondedzero yehunhu hwayo, kushandiswa, kugadzira uye ruzivo rwekuchengetedza:

Zvakasikwa:
Fmoc-O-tert-butyl-D-tyrosine ikristaro chena yakasimba. Iyo organic compound ine kemikari formula C30H31NO7 uye molecular uremu hwe521.57g/mol. Mushonga wacho unobva ku tyrosine umo boka reamino rinotakura Fmoc (9-fluorofluorenylformyl) boka rinodzivirira uye boka re carboxylic acid rinosimbiswa neO-tert-butyl.

Shandisa:
Fmoc-O-tert-butyl-D-tyrosine inowanzoshandiswa seyakachengetedzwa amino acid mu peptide synthesis. Nekubatanidza iyo Fmoc inodzivirira boka kuboka reamino, zvisingadiwe mativi maitiro anogona kudzivirirwa panguva yekubatanidza. Inoshandiswa zvakanyanya mune yakasimba chikamu synthesis uye inogona kushandiswa kugadzira polypeptides uye mapuroteni.

Kugadzirira nzira:
Kugadzirira kweFmoc-O-tert-butyl-D-tyrosine kunowanzoitwa nemakemikari synthesis. Kutanga, tyrosine inobatwa neFmoc-Cl (9-fluorofluorenylcarbonyl chloride) kugadzira Fmoc-O-tyrosine. Cesium tert-butyl bromide inozowedzerwa kune maitiro esterify boka re carboxylic acid kuti riumbe Fmoc-O-tert-butyl-D-tyrosine. Pakupedzisira, chigadzirwa chakachena chinowanikwa nematanho ekristalllization, kushambidza uye kuomesa.

Zvekuchengetedza
Fmoc-O-tert-butyl-D-tyrosine isanganiswa yakagadzikana pasi pemamiriro akajairika uye haina kuvhurika kuri pachena pakupisa kwekamuri. Panguva yekushandiswa, zvinodikanwa kutevedzera nzira dzekuchengetedza marabhoritari, kupfeka midziyo yekudzivirira yakakodzera, uye kudzivirira kusangana neganda nemeso. Paunenge uchibata kana kuchengetedza, inofanira kuchengetwa munzvimbo yakaoma, inotonhorera uye kure nemoto uye oxidizing agents. Panguva imwecheteyo, kusangana nemaoxidants akasimba uye maasidhi akasimba kunofanirwa kudziviswa kudzivirira kuita kwengozi. Tsvaka rubatsiro rwekuchipatara kana ukamwisa kana kuti wasangana nemukomboni netsaona.