L-Pyroglutamic acid CAS 98-79-3

Chemical Property:

Molecular Formula	C5H7NO3
Molar Misa	129.11
Density	1.3816 (yakaomarara fungidziro)
Melting Point	160-163°C(lit.)
Boling Point	239.15°C (yakaomarara fungidziro)
Kutenderera kwakananga(α)	-27.5 º (c=10, 1 N NaOH)
Flash Point	227.8°C
Mvura Solubility	10-15 g/100 mL (20 ºC)
Solubility	Soluble mumvura, doro, acetone uye glacial acetic acid, zvishoma soluble mu ethyl acetate, isinganyunguriki mu ether.
Vapor Presure	0.002Pa pa25 ℃
Chitarisiko	Ikiristati yakachena
Color	Muchena kusvika kure-chena
Merck	14,8001
BRN	82132
pKa	3.32(pa25℃)
PH	1.7 (50g/l, H2O, 20℃)
Storage Condition	2-8°C
Kugadzikana	Yakagadzikana. Hazvienderani nemabhesi, acids, yakasimba oxidizing agents.
Refractive Index	-10 ° (C=5, H2O)
MDL	MFCD00005272
Zvenyama uye Chemical Properties	Kunyungudika 152-162°C chaiyo optical kutenderera -27.5 ° (c = 10, 1 N NaOH) mvura inonyungudika 10-15g/100 mL (20°C)
Shandisa	Inoshandiswa mukudya, mishonga, cosmetics uye mamwe maindasitiri

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Ngozi uye Kuchengeteka

Hazard Symbols	Xi – Hasha
Risk Codes	36/37/38 - Kushungurudza maziso, kufema system uye ganda.
Tsanangudzo Yekuchengetedza	S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa. S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera. S37/39 - Pfeka magirovhosi akakodzera uye dziviriro yeziso / kumeso
WGK Germany	3
RTECS	TW3710000
FLUKA BRAND F CODES	21
TSCA	Ehe
HS Code	29337900

Nhanganyaya	pyroglutamic acid ine 5-oxyproline. Inoumbwa nekuderera kwemvura pakati pe-α-NH2 boka uye γ-hydroxyl boka re glutamic acid kuti riite molecular lactam bond; Inogonawo kuumbwa nekurasikirwa neboka reAmido mune glutamine molecule. Kana kushomeka kweglutathione synthetase kunogona kukonzera pyroglutamemia, nhevedzano yezviratidzo zvekiriniki. Pyroglutamemia chirwere che organic acid metabolism chinokonzerwa nekushomeka kweglutathione synthetase. Clinical zviratidzo zvekuzvarwa 12 ~ 24 maawa ekutanga, kufambira mberi kwehemolysis, jaundice, kusingaperi Metabolic Acidosis, kusagadzikana kwepfungwa, nezvimwewo; Weti ine pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Kurapa, symptomatic, teerera kugadzirisa kudya mushure mezera.
properties	L-pyroglutamic acid, inozivikanwawo seL-pyroglutamic acid, L-pyroglutamic acid. Kubva pamusanganiswa we ethanol ne petroleum ether mukunaya kwe Crystal isina ruvara orthorhombic kaviri koni, inonyungudika ye162~163 ℃. Soluble mumvura, doro, acetone uye acetic asidhi, ethyl acetate-soluble, insoluble mu ether. Chaicho optical rotation -11.9 °(c = 2,H2O).
Zvimiro uye kushandiswa	muganda remunhu rine basa rekunyorovesa remvura-inonyungudika zvinhu-zvakasikwa moisturizing factor, kuumbwa kwayo kunenge amino acid (ine 40%), pyroglutamic acid (ine 12%), inorganic munyu (Na, K, Ca, Mg, nezvimwewo. ine 18.5%), uye mamwe organic compounds (ane 29.5%). Naizvozvo, pyroglutamic acid ndechimwe chezvikamu zvikuru zveganda natural moisturizing factor, uye kugona kwayo kunyorovesa kunopfuura nekure kweglycerol uye propylene glycol. Uye isiri-chepfu, isina kukurudzira, ndeyemazuva ano Ganda Care, Bvudzi Care zvizoro zvakanakisa zvigadzirwa. Pyroglutamic acid inewo inhibitory mhedzisiro pabasa re tyrosine oxidase, nekudaro ichidzivirira kuiswa kwe "melanoid" zvinhu muganda, izvo zvine chena ganda paganda. Iine kupfava paganda, inogona kushandiswa kwezvipikiri zvizorwa. Pamusoro pekushandiswa mune zvizorwa, L-pyroglutamic acid inogonawo kuburitsa madhirivative nemamwe organic compounds, ane akakosha mhedzisiro pamabasa epamusoro, akajeka uye akajeka maitiro, etc. Inogonawo kushandiswa se surfactant ye detergents; Kemikari reagents yekugadziriswa kwemamineramic amines; Organic intermediates.
nzira yekugadzirira	L-pyroglutamic acid inoumbwa nekubvisa miniti imwe yemvura kubva kune molecule yeL-glutamic acid, uye maitiro ayo ekugadzirira ari nyore, matanho anokosha ndiwo kutonga kwekushisa uye nguva yekudzikisa. (1) 500g yeL-glutamic acid yakawedzerwa kune 100 ml beaker, uye beaker yakapiswa nemafuta ekugezera, uye tembiricha yakasimudzwa kusvika 145 kusvika 150 ° C., uye tembiricha yakachengetedzwa kwemaminetsi makumi mana neshanu nekuda kwekupera mvura. reaction. Mushonga wakapera mvura waiva Tan. (2) mushure mekupedzwa kwekuita kwekushaya mvura, mhinduro yakadururwa mumvura inopisa nehuwandu hwe350, uye mhinduro yacho yakanyungudika zvachose mumvura. Mushure mekutonhodza kusvika ku40 kusvika ku50 ° C., huwandu hwakakodzera hwekabhoni yakabatidzwa yakawedzerwa kuti iite decoloration (yakadzokororwa kaviri). Mushonga usina ruvara wakajeka wakawanikwa. (3) kana iyo isina ruvara inopenya mhinduro yakagadziriswa munhanho (2) yakanyatso kudziya uye nekunyungudutswa kuti ideredze vhoriyamu kusvika hafu, tendeukira kune yekugezera yemvura uye ramba uchitarisa kune vhoriyamu inosvika 1/3, unogona kumisa kupisa, uye mumvura inopisa yekugezera kuti inonoke kupenya, 10 kusvika maawa 20 mushure mekugadzirwa kwekrismatic crystals isina ruvara. Huwandu hweL-pyroglutamic acid muzvizoro zvinoenderana nekugadzirwa. Ichi chigadzirwa chinogona zvakare kushandiswa pazvizoro muchimiro che50% concentrated solution.
glutamic acid	glutamic acid is amino acid inoumba puroteni, ine ionized acidic side chain, uye inoratidza hydrotropism. Glutamic acid inotapukirwa ne cyclization mu pyrrolidone carboxylic acid, I.e., pyroglutamic acid. glutamic acid inonyanya kukwira mumapuroteni ese ezviyo, achipa alpha-ketoglutarate kuburikidza ne tricarboxylic acid cycle. Alpha ketoglutaric acid inogona kugadzirwa zvakananga kubva kuammonia pasi pe catalysis ye glutamate dehydrogenase uye NADPH (coenzyme II), uye inogonawo kugadziriswa ne aspartate aminotransferase kana alanine aminotransferase, glutamic acid inobudiswa ne transamination ye aspartic acid kana alanine; Mukuwedzera, glutamic acid inogona kuchinjwa kuchinjwa neproline uye ornithine (kubva kuarginine), maererano. Glutamate saka ine hutano husina kukosha amino acid. Kana glutamic acid yakasvibiswa pasi pe catalysis ye glutamate dehydrogenase uye NAD (coenzyme I) kana kuti inotamiswa kunze kweboka reamino pasi pe catalysis ye aspartate aminotransferase kana alanine aminotransferase kuti ibudise alpha ketoglutarate, inopinda mu tricarboxylic acid cycle uye inogadzira shuga kuburikidza ne gluconeogenic nzira, saka glutamic asidhi yakakosha glycogenic amino acid. glutamic acid mumatishu akasiyana (semhasuru, chiropa, uropi, nezvimwewo) inogona kugadzira glutamine neNH3 kuburikidza necatalysis ye glutamine synthetase, ndiyo detoxification chigadzirwa cheammonia, kunyanya mumatishu ehuropi, uyezve nzira yekuchengetedza nekushandisa. ammonia mumuviri (ona "glutamine uye metabolism yayo"). glutamic acid inogadzirwa neacetyl-CoA se cofactor ye mitochondrial carbamoyl phosphate synthase (inobatanidzwa mukugadzirwa kwe urea) kuburikidza necatalysis yeacetyl-glutamate synthase. γ-aminobutyric acid (GABA) chigadzirwa che decarboxylation ye glutamic acid, kunyanya muhuwandu hwehuwandu hwehuropi, uye zvakare inoonekwa muropa, kushanda kwayo kwemuviri kunoonekwa se inhibitory neurotransmitter, antispasmodic uye hypnotic mhedzisiro inoitwa ne kliniki infusion ye echinocandin inogona kuwanikwa kuburikidza neGABA. Iyo catabolism yeGABA inopinda mu tricarboxylic acid cycle nekushandura GABA transaminase uye aldehyde dehydrogenase kuita succinic acid kuumba GABA shunt.
Shandisa	inoshandiswa sepakati mune organic synthesis, chikafu chekuwedzera, nezvimwe. inoshandiswa mune zvekudya, mishonga, cosmetics nemamwe maindasitiri