Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Ngozi uye Kuchengeteka
| Hazard Kirasi | 6.1 |
Nzira yekugadzira
chidimbu chakanangwa chakagadzirwa neoxidation, amidation uye kupera simba nemethyl 2-methyl 4-pyridinecarboxylate (2) sechinhu chekutanga. chimiro chayo chakasimbiswa ne1H NMR neMS, uye goho rose raive 53.0%. Mhedzisiro yekudyisa chiyero, tembiricha yekristaro, nguva yekuita uye zvimwe zvinhu pachigadzirwa zvakadzidzwa ne-single-factor experiments, uye maitiro ekugadzirisa akagadziridzwa: n (2): n (potassium permanganate) = 1.0: 2.5, crystallization tembiricha 0. ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0:1.4, kuita; iyo dehydration reaction inosarudza iyo trifluoroacetic anhydride-triethylamine system seyo dehydrating agent. Maitiro acho ari nyore kushanda, maitiro ekuita akapfava, ari nyore kukwidza kugadzirwa, uye ane yakanaka inoshanda kukosha kwekushandisa.
Shandisa
Tobisostat inoshandiswa kurapa chisingaperi hyperuricemia ye gout. Kuenzaniswa nemishonga yechinyakare allopurinol (purine analog), haizokanganisa purine uye pyridine metabolism uye enzyme basa, uye inoderedza uric acid Mhedzisiro yacho yakasimba, hapana chiyero chikuru chinodzokororwa chinodiwa, uye kuchengetedzwa kuri nani. Methyl 2-cyano-4-pyridine carboxylate chinhu chakakosha mbishi kugadzirwa kweTobiso.
