Mitotan (CAS# 53-19-0)

Chemical Property:

Molecular Formula	C14H10Cl4
Molar Misa	320.04
Density	1.3118 (yakaomarara fungidziro)
Melting Point	77-78°C(lit.)
Boling Point	405.59°C (yakaomarara fungidziro)
Mvura Solubility	<0.1 g/100 mL pa24 ºC
Solubility	DMSO: soluble20mg/mL, yakajeka
Chitarisiko	upfu
Color	kuchena kune beige
Merck	13,6237 / 13,6237
BRN	2056007
Storage Condition	Inert mamiriro, Room Temperature
Refractive Index	1.6000 (kufungidzira)
Zvenyama uye Chemical Properties	Kunyungudika 76-78°C mvura-inonyungudika <0.1g/100 mL pa24°C
Shandisa	Ichi chigadzirwa ndechekutsvagisa sainzi chete uye hachifanire kushandiswa kune zvimwe zvinangwa.
In vitro kudzidza	Mune mbeva yeTalphaT1 cell line, Mitotane inhibits kutaura uye secretion yeTSH, inovhara mhinduro yeTSH kune TRH, uye inoderedza kushanda kwesero, uye induces apoptosis. Mune pituitary TSH-secreting mouse cells, Mitotane haipindirani nehomoni yehomoni, asi inoderedza zvakananga basa rekuvhara uye kushandiswa kwesero. Mitotane induces adrenal cortical necrosis, mitochondrial membrane kukuvara, uye isingachinjiki kusunga kuprotein CYP. Mitotane (10-40 μm) inhibited basal uye cAMP-induced cortisol secretion asi haina kukonzera sero kufa. Mitotane yakaratidza inhibitory effects pabasal Star uye P450scc mapuroteni. Mitotane (40 μm) yakaderedza zvakanyanya mRNA mazinga eStart, CYP11A1 uye cyp21. Mitotane (40 μm) yakapotsa yabvisa zvachose kuiswa kwe STAR, CYP11A1, CYP17, uye CYP21 mRNA neadenosine 8-bromo-cyclic phosphate. Muchikamu cheS chemasero eH295R, kusanganiswa kweMitotane uye gemcitabine kwakaratidza kupesana uye kupindira nekudzivisa gemcitabine-mediated inhibition muchitokisi.
In vivo kudzidza	Mumakonzo, Mitotane (60 mg / kg) yakaderedza zvakanyanya adrenal mitochondrial uye microsomal "P-450" uye microsomal proteins ne 34%,55% uye 35%.

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Product Detail

Product Tags

Hazard Symbols	Xn – Zvinokuvadza
Risk Codes	40 - Uchapupu hushoma hwechirwere checarcinogenic
Tsanangudzo Yekuchengetedza	36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
UN IDs	3249
WGK Germany	3
RTECS	KH7880000
HS Code	2903990002
Hazard Kirasi	6.1(b)
Packing Group	III

Nhanganyaya

Mitotane musanganiswa wemakemikari ane zita rekuti N,N'-methylene diphenylamine. Izvi zvinotevera sumo kune zvivakwa, kushandiswa, nzira dzekugadzirira uye ruzivo rwekuchengetedza mitotane:

Hunhu:

- Mitotane is a colorless crystalline solid inonyungudika muorganic solvents senge ethanol, ether, uye chloroform.

- Mitotane ine kunhuhwirira kwakasimba.

Shandisa:

- Mitotane inonyanya kushandiswa pakubatanidza maitiro mu organic synthesis uye inowanzoshandiswa se reagent uye catalyst.

- Inogona kutora chikamu mukusiyana kwemakemikari kuita, sekubatanidza alkynes, alkylation yeanonhuhwirira makomisheni, nezvimwe.

Nzira:

- Mitotane inogona kugadzirwa nemaitiro maviri-nhanho. Formaldehyde inobatwa ne diphenylamine pasi pemamiriro ealkaline kuita N-formaldehyde diphenylamine. Zvadaro, ne pyrolysis kana controlled oxidation reaction, inoshandurwa kuva mitotane.

Zvekuchengetedza

- Mitotane inhengo inogumbura uye haifaniri kusvika pakatarisana neganda nemaziso. Midziyo yekudzivirira yakakodzera senge magirovhosi, magirovhosi, nembatya dzekudzivirira zvinofanirwa kupfekwa pakushanda.

- Paunenge uchichengeta uye uchibata, chenjerera kuvhara uye kudzivirira kubva kuchiedza kuti usasangana nemhepo uye unyoro.

- Mitotane inoora pakupisa kwepamusoro kuti ibudise magasi ane chepfu, kudzivisa kupisa kana kusangana nezvimwe zvinhu zvinopisa.

- Tarisa kune mirau yemunharaunda uye uteedzere maitiro ekuchengetedza akakodzera kana uchirasa.

Zvakapfuura: 4-(4-methoxyphenyl)-1-butanol(CAS# 52244-70-9)

Zvinotevera: 2-Chloro-5-aminopyridine (CAS# 5350-93-6)

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