N(alpha)-fmoc-N(epsilon)-(2-chloro-Z)-L-lysine(CAS# 133970-31-7)

Fmoc-(2-chlorobenzyloxycarbonyl) lysine chinhu chinowanzo shandiswa amino acid chinobva kune zvinotevera:1. Kuonekwa: white crystalline powder;
2. molecular formula: C26H24ClNO5;
3. Huremu hwemamorekuru: 459.92g/mol;
4. Solubility: Soluble in organic solvents yakadai sedimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dichloromethane, nezvimwewo, isingagadziriswi mumvura;
5. Kunyunguduka: inenge 170-175 ° C. Kushandiswa kwekutanga kweFmoc-(2-chlorobenzyloxycarbonyl) lysine iboka rinodzivirira uye rinoita basa mukubatanidzwa kwepolypeptides. Boka rayo recarboxyl rinogona kuvhurwa kuti riite ester, iyo inobva yaita condensation reaction ine amino acid inosara kuti igadzire cheni yepolypeptide. Boka reFmoc rinogona kubviswa nyore nyore mushure mekuita kwapera kuratidza yakachengetedzwa amino moiety.

Nzira yekugadzira Fmoc-(2-chlorobenzyloxycarbonyl) lysine inowanzobatanidza matanho anotevera:

1. kuita lysine neN-hydroxybutyrimide (Pbf) kuunza boka rinodzivirira;
2. reacting lysine-Pbf derivative ne 2-chlorobenzyl doro kuumba Fmoc-(2-chlorobenzyloxycarbonyl) lysine;
3. Chigadzirwa chacho chinobudiswa nemushonga wakakodzera uye unocheneswa nekristalllization kuti uwane chigadzirwa chakachena.

Nezve ruzivo rwekuchengetedza, Fmoc-(2-chlorobenzyloxycarbonyl) lysine ikemikari reagent uye matanho akakodzera ekuchengetedza anofanirwa kutorwa. Midziyo yekudzivirira yakakodzera, senge magurovhosi erabhu, magirazi, uye zvipfeko zvemurabhoritari, zvinofanirwa kupfekwa panguva yekuyedza. Dzivisa kufemba poda kana mishonga, dzivisa kusangana neganda nemaziso. Kana wasangana netsaona, sukurudza nekukasika nemvura yakawanda uye tsvaga rubatsiro kuna chiremba. Ita shuwa kuti inoshandiswa munzvimbo yakachengeteka murabhoritari uye yachengetwa nemazvo kudzivirira tsaona.