N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)

Nhanganyaya

Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) ikemikari ine zvinhu zvinotevera:

Zvakasikwa:

1. Kuonekwa: kuchena kwakasimba

2. molecular formula: C21H25N3O6S

3. molecular uremu: 443.51

4. Kunyungudika: inenge 110-115°C

Shandisa:

Boc-D-His(Tos) -OH inowanzoshandiswa muorganic synthesis seboka rinodzivirira reD-histidine (D-His). Kunyanya kushandiswa kwayo kunosanganisira:

1. Mukugadzirwa kwepolypeptide, inoshandiswa kugadzira polypeptide sequence ine D-histidine boka rekudzivirira.

2. Inoshandiswa seyepakati mumunda wekemikari yemishonga yekugadzirwa kwebiologically active target compounds.

3. Dhizaini uye kuumbwa kwemishonga yevamiriri vezvinodhaka mukutsvaga.

Kugadzirira nzira:

Kugadzirira kweBoc-D-His(Tos)-OH kunowanzoitwa nematanho anotevera:

1. D-histidine (D-His) yakabatwa ne p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) kupa D-histidine p-toluenesulfonyl (D-His-Tos).

2. Pasi pemamiriro e-alkaline, D-His-Tos inoshandiswa ne n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) kugadzira Boc-D-His (Tos) -OH.

Zvekuchengetedza

Kuongororwa kwekuchengetedza kweBoc-D-His(Tos)-OH ishoma, asi sechinhu chemakemikari, zvinotevera zvekuchengetedza zvinofanirwa kucherechedzwa:

1. Dzivisa inhalation, kubata neganda uye maziso. Pfeka midziyo yekuzvidzivirira nayo yakakodzera, yakadai segirovhosi nemagirazi.

2. Maitiro akanaka erabhoritari anofanirwa kuteverwa panguva yekushandiswa uye mamiriro akanaka ekufema anofanira kuve nechokwadi.

3. Chengetedza mumudziyo wakavharwa, kure nemoto uye oxidant.

4. Tevera mitemo yakakodzera uye mazano panguva yekugadzirisa.

Paunenge uchishandisa Boc-D-His(Tos)-OH, ndapota iva nechokwadi chekutevera mirairo yekuchengetedzwa kwerabhoritari uye mirairo yekushandisa, uye chengetedza uye ubate makemikari nemazvo. Kana zvichidikanwa, zvinokurudzirwa kushanda pasi pekutungamirirwa kwevashandi.