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Nicorandil(CAS# 65141-46-0) Featured Image
  • Nicorandil(CAS# 65141-46-0) 1

Nikorandil (CAS# 65141-46-0)

Chemical Property:

Molecular Formula C8H9N3O4
Molar Misa 211.17
Density 1.4271 (yakaomarara fungidziro)
Melting Point 92°C
Boling Point 350.85°C (yakaomarara fungidziro)
Flash Point 230°C
Solubility DMSO:> 10 mg/mL. Soluble mu methanol, ethanol, acetone kana glacial acetic acid, inonyungudika zvishoma muchloroform kana mvura, inenge isinganyunguriki muether kana benzene.
Vapor Presure 1.58E-08mmHg pa25°C
Chitarisiko Muchena kusvika kuchena-kunge crystalline powder
Color chena kusvika kure-chena
Merck 14,6521
Storage Condition 2-8°C
Refractive Index 1.7400 (kufungidzira)
MDL MFCD00186520
Zvenyama uye Chemical Properties White crystalline poda, isinganhuhwi kana kuti inonhuwa zvishoma, inovava. Soluble mu methanol, ethanol, acetone kana acetic acid, inonyungudika zvishoma muchloroform kana mvura, mashoma haanyungudike muether kana benzene. Kunyungudika 88.5-93.5 °c. Acute toxicity LD50 rats (mg/kg): 1200-1300 nemuromo, 800-1000 intravenous.
Shandisa Nekudzivirira kwechirwere chemoyo, angina pectoris
In vitro kudzidza Nicorandil (100 mM) yakawedzera flavoprotein oxidation, asi haina kukanganisa membrane ikozvino, kudzoreredza mitoK (ATP) uye pamusoroK (ATP) migero pamatunhu akakwirira kupfuura 10-fold. Nicorandil inoderedza kufa kwesero mune ischemic granulation model, cardioprotective effect iyo yakavharwa ne mitoK(ATP) channel blocker 5-hydroxydecanoic acid asi kwete nepamusoroK(ATP). Mhedzisiro yechiteshi blocker HMR1098. Nicorandil (100 mM) inodzivisa kurasikirwa kweTUNEL positivity, cytochrome C translocation, caspase-3 activation, uye mitochondrial membrane inogona (Delta (Psi) (m)). Kuongororwa kwemasero akasvibiswa nefluorescence Delta (Psi) (m) -chiratidzo, tetramethylrhodamine ethyl ester (TMRE) nefluorescence activated cell sorter yakaratidza kuti, nicorandil inodzivirira Delta (Psi) (m) depolarization nenzira inotsamira (EC (50). ) angangoita 40 mM, saturation 100 mM). Mumasero ese akatapurirwa, Nikorandil yakamisa isina kusimba mukati kugadzirisa, glibenclamide-inonzwa 80 pS K chiteshi. MuHEK293T maseru, Nicorandil anonyanya kushandisa iyo K(ATP) chiteshi ine SUR2B. Nicorandil (100 mM) yakavhara zvakanyanya nhamba yemasero muTUNEL-positive nuclei uye yakawedzera 20 mM h2o2-induced caspase-3 basa. Nicorandil concentration-inovimba inodzivirira kurasikirwa kweDeltaPsim kunokonzerwa neH2O2.
In vivo kudzidza Nicorandil (2.5 mg / kg zuva nezuva, po) pamwe chete neAmlodipine (5.0 mg / kg zuva rega rega, po) mazuva matatu echiito akadzivirira zvakanyanya kuchinja uye kudzoreredza basa re enzyme kusvika kumazinga ari pedyo neaya emakonzo akajairika.

Product Detail

Product Tags

Hazard Symbols Xn – Zvinokuvadza
Risk Codes R22 – Zvinokuvadza kana ikamedzwa
R41 - Njodzi yekukuvara kwakakomba kwemaziso
Tsanangudzo Yekuchengetedza S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa.
S39 - Pfeka dziviriro yeziso / kumeso.
WGK Germany 3
RTECS US4667600
HS Code 29333990
Muchetura LD50 mumakonzo (mg / kg): 1200-1300 nemuromo; 800-1000 iv (Nagano)

 

Nhanganyaya

Nicolandil, inozivikanwawo se nicorandil amine, ndeye organic compound. Iyi inotevera sumo kune zvivakwa, mashandisiro, kugadzirira uye kuchengetedza ruzivo rwe nicorandil:

 

Hunhu:

- Nicorandil is colorless crystalline solid inonyungudika mumvura uye organic solvents.

- Iyo alkaline komputa inogona kuita nemaasidhi kugadzira munyu makemikari.

- Nicorandil yakagadzikana mumhepo, asi inogona kuora kana yaratidzwa kune yakanyanya kupisa.

 

Shandisa:

- Nicolandil inogona zvakare kushandiswa mukubatanidza kweorganic synthesis catalysts, photosensitizers, nezvimwe.

 

Nzira:

- Nicolandil inowanzogadzirirwa nekuita kwe dimethylamine uye 2-carbonyl compounds.

-Kuita kunoitwa pasi pemamiriro ealkaline uye maitiro ekupisa anoitwa mune yakakodzera solvent.

 

Zvekuchengetedza

- Nicorandil yakachengeteka kune vanhu pasi pemamiriro ezvinhu.

- Zvisinei, kutarisirwa kunofanira kutorwa kuti udzivise kusangana kwakananga nemaziso, ganda, uye kufema.

- Pfeka midziyo yekudzivirira yakafanira (PPE) senge magirazi ekuchengetedza, magurovhosi nemidziyo yekufema.

- Paunenge uchishandisa kana kuchengetedza nicorandil, kutarisirwa kunofanira kutorwa kudzivirira kupisa uye kupisa kwakanyanya.

 

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