Papaverine Hydrochloride(CAS#61-25-6)
| Risk Codes | R22 – Zvinokuvadza kana ikamedzwa R34 – Inokonzera kusvirwa R11 - Inopisa zvakanyanya |
| Tsanangudzo Yekuchengetedza | S22 - Usafeme guruva. S45 - Kana waita tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga rubatsiro rwekuchipatara nekukasika (ratidza chinyorwa pese pazvinogoneka.) S36/37/39 - Pfeka zvipfeko zvekudzivirira zvakakodzera, magurovhosi uye kudzivirira kweziso/chiso. S26 – Kana wasangana nemaziso, sukurudza nekukurumidza nemvura yakawanda uye tsvaga mazano ekurapwa. S16 - Chengetedza kure nenzvimbo dzekudzima. |
| UN IDs | UN 1544 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | NW8575000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Ehe |
| HS Code | 29391900 |
| Hazard Kirasi | 6.1 |
| Packing Group | III |
| Muchetura | LD50 mumakonzo, makonzo (mg/kg): 27.5, 20 iv; 150, 370 sc (Levis) |
Papaverine Hydrochloride(CAS#61-25-6)
Papaverine hydrochloride, nhamba yeCAS 61-25-6, inhengo inokosha mumunda wemishonga.
Kubva pakuona kwemaitiro emakemikari, ndiyo hydrochloride fomu yepapaverine, uye chimiro chemakemikari chinotarisa maitiro ayo. Kurongeka kwemaatomu uye kurongeka kwemakemikari bond muchimiro chemolecular zvinopa kugadzikana kwakasiyana uye kuitazve. Chitarisiko chinowanzo chena kusvika kuchiedza yero crystalline poda, iyo inobatsira pakugadzirisa, kuchengetedza uye kutakura zvinodhaka. Panyaya yekunyungudika, ine mwero mukunyungudika mumvura, uye akasiyana-asidhi-base nharaunda uye tembiricha mamiriro anozokanganisa kunyungudika kwayo, izvo zvakakosha pakugadzirwa kwemishonga, kugadzirwa kwemafomu ekuyeresa, uye maitiro ekuona yunifomu. kupararira kwezvinodhaka paunenge uchigadzira majekiseni uye kugadzirira nemuromo.
Panyaya yezve pharmacological efficacy, Papaverine Hydrochloride ndeyekirasi yeakatsetseka tsandanyama inozorodza. Inonyanya kushanda pamusungo wakatsetseka wetsinga dzeropa, gastrointestinal turakiti, biliary turakiti uye zvimwe zvikamu, uye inokurudzira kusununguka kwemhasuru yakatsetseka nekuvhiringidza nzira dzakaita senge intracellular calcium ion transport. Kliniki, inowanzoshandiswa kurapa ischemia inokonzerwa nevasospasm, yakadai semusoro uye chizuru chinokonzerwa necerebral vasospasm, iyo inogona kuvandudza kupararira kweropa; Iyo inewo yakakosha kudzikisa mhedzisiro pamarwadzo emudumbu uye biliary colic inokonzerwa negastrointestinal spasm, kuderedza marwadzo evarwere.
Zvisinei, sezvinoitwa nemishonga yakawanda, zvakakosha kutevera mirairo yachiremba wako paunenge uchiishandisa. Nekuda kwemabasa akasiyana emuviri uye zvirwere zviri pasi pemurwere wega wega, vanachiremba vanofanirwa kuyera zvakakwana zera remurwere, chiropa neitsvo, mamwe madhiragi ari kutorwa uye zvimwe zvinhu, uye kunyatsoona dhigirii, nzira yekutonga uye nzira yekurapa. sekuona kuti mushonga hauna njodzi uye unoshanda, uye kubatsira murwere kuti apore. Nekufambira mberi kwekutsvagisa kwesainzi, kutsvagisa nekuvandudzwa kwemafomu matsva edosi uye optimization yemishonga yakasanganiswa yakaitenderedza iri kupisa zvakare.
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