tert-butyl 2 4-dioxopiperidine-1-carboxylate (CAS# 845267-78-9)

Molecular Formula	C10H15NO4
Molar Misa	213.23
Density	1.199
Boling Point	373.8±35.0 °C(Zvakafanotaurwa)
Flash Point	179.9°C
Vapor Presure	8.72E-06mmHg pa25°C
pKa	10.67±0.20(Zvakafanotaurwa)
Storage Condition	Ramba uri munzvimbo ine rima, Yakavharwa pakaoma, Kamuri Tembiricha
Refractive Index	1.493
MDL	MFCD10566071

Product Detail

Risk Codes	20/21/22 - Zvinokuvadza nekufemesa, kusangana neganda uye kana ikamedzwa.
Tsanangudzo Yekuchengetedza	S23 - Usafeme mhute. S24/25 - Dzivisa kusangana neganda nemeso.
WGK Germany	3
HS Code	29337900

Shandisa	2, 4-dipiperidon-1-formate tert-butyl formate ndiyo inoshandiswa ye phenoxymethyl-dihydrothiazolopyridone derivatives Reactants mune chigadzirwa, sechisarudzo chakanaka chekugadzirisa modulator (PAM) ye metabolized glutamate 5 (mGlu5) receptor.
application	2, 4-dioperidone-1-tert-butyl formate inonyanya kushandiswa seyepakati uye yepakati yemishonga yepakati, uye inogona kushandiswa murabhoritari yekutsvaga nekuvandudza maitiro uye makemikari mushonga synthesis process.
kugadzirira	danho a: wedzera EDCI(191.7g) kuDMF(400mL) mhinduro ye3-(tert-butoxycarbonylamino) propionic acid (189.2g,1.0mol), meldamic acid (144.1g,1.0mol) uye DMAP(135.0g,1.1mol) ) yakatonhodzwa nekugeza echando, 1.0mol). Izvo zvinokonzeresa reactants zvakamutswa usiku hwose pakamuri tembiricha. Mhinduro yacho yakadzimwa ne200mL H2O. Musanganiswa unoguma wakawedzerwa kudonhedza kuH2O (2.0L) pasi pemechani inomutsa. Iyo yakawanikwa yakasimba yakasefa uye yakanyatsogezwa nemvura kusvika pH 7 kuti uwane chigadzirwa (283g,90% goho). Danho B: Mushonga we3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl)-3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) mu toluene (1500mL) inopisa pa 100 ° C kwemaawa mana. Iwo mareactants anotonhodzwa kusvika kukamuri tembiricha uye anonamirwa pasi pekumanikidzwa kwakaderedzwa kuwana chigadzirwa chisina kuchena. Chigadzirwa (56g, 83% goho) chakanatswa neMTBE-kugaya.