Tetrahydropapaverine hydrochloride(CAS#6429-04-5)
Tetrahydropapaverine hydrochloride (CAS # 6429-04-5) musanganiswa unobata zvakakosha muminda yakaita semushonga.
Zvinotaridzika, inowanzoita senge chena crystalline poda ine yakanaka solid-state kugadzikana, zvichiita kuti zvive nyore kuchengeta nekutakura. Panyaya yekunyungudika, ine imwe dhigirii yekunyungudika mumvura, iyo inobvumira kuti iparadzwe zviri nani mumidhiya ine aqueous pakuita gadziriro dzakabatana. Panguva imwecheteyo, inogona zvakare kuratidza humwe hunhu hwekunyungudika mune mamwe organic solvents, senge methanol, ethanol uye mamwe doro organic solvents.
Kubva pachimiro chemakemikari chimiro, chimiro chayo chemorekuru chine yakakosha nitrogen-ine heterocyclic moiety, iyo inoiisa ine yakasarudzika pharmacological chiitiko chine chekuita. Inogona kudyidzana nezvimwe zvibodzwa zvinonangwa mumutumbi, senge chaiwo mareceptor, ma enzymes, nezvimwewo, uye kuita zvinoenderana ne physiological regulatory mhedzisiro. Uyezve, kuvapo kwehydrochloric acid hakungowedzere kunyungudika kwekomboni yese mumvura, asi kunokanganisa kugadzikana kwayo kwemakemikari uye zvinhu zvine chekuita nazvo senge zvinodhaka metabolism kune imwe nhanho.
Mundima yekushandisa, inonyanya kushandiswa muindasitiri yemishonga sechinhu chinoshanda chemishonga, chinowanzo shandiswa kuderedza zvirwere zvine hukama senge vascular spasm. Nekuzorodza vascular smooth tsandanyama uye kuvandudza kutenderera kweropa kwenzvimbo, ine mhedzisiro yakanaka pakurapa adjuvant yeimwe yemwoyo uye cerebrovascular zvirwere, uye inogona kubatsira kuderedza kusagadzikana kwezviratidzo zvinokonzerwa nevascular spasm uye kuvandudza hupenyu hwevarwere.
Panguva yekuchengetedza uye kushandiswa, zvakakosha kuiisa munzvimbo yakavharwa uye yakaoma kuti urege kunyorova, sezvo unyoro hunogona kukanganisa kugadzikana kwayo kwemakemikari uye crystalline state. Panguva imwecheteyo, inofanira kuchengetwa pasi pemamiriro ekushisa akatemerwa, kure nemamiriro ekushisa kwepamusoro, kudzivirira kuora uye denaturation, uye kunyatsotevera mitemo yakakodzera yekuchengetedza zvinodhaka uye kushandiswa kuve nechokwadi chekuchengetedzwa uye kushanda kwemishonga.
